Tedizolid-Rifampicin Combination Prevents Rifampicin-Resistance on in vitro Model of Staphylococcus aureus Mature Biofilm

Titanium-Tethered Vancomycin Prevents Resistance to Rifampicin in Staphylococcus aureus in vitro

Rifampicin is currently recognized as the most potent drug against Gram positive implant related infections. The use of rifampicin is limited by the emergence of bacterial resistance, which is often managed by coadministration of a second antibiotic. The purpose of this study was to determine the effectiveness of soluble rifampicin in combination with vancomycin tethered to titanium metal as a ...

Rifampicin fails to eradicate mature biofilm formed by methicillin-resistant Staphylococcus aureus.

INTRODUCTION Antimicrobial activity on biofilms depends on their molecular size, positive charges, permeability coefficient, and bactericidal activity. Vancomycin is the primary choice for methicillin-resistant Staphylococcus aureus (MRSA) infection treatment; rifampicin has interesting antibiofilm properties, but its effectivity remains poorly defined. METHODS Rifampicin activity alone and i...

Factors affecting development of rifampicin resistance in biofilm-producing Staphylococcus epidermidis.

Selection and regrowth of variants resistant to 0.016-32 mg/L of rifampicin, which were present at a frequency of 10(-7) in the initial inoculum, were seen when large inocula (> 10(5) cfu/mL) of Staphylococcus epidermidis ATCC 35984 were incubated with the drug. Conventional MIC determinations using approximately 10(5) cfu/mL did not detect the resistant variants. Larger inocula increased the M...

Community-acquired methicillin-resistant Staphylococcus aureus in bone and joint infections: development of rifampicin resistance.

Despite this, one constant remains. At the core of medical professionalism is the social contract granting a privilege to provide services, underpinned by expert knowledge and skills, ethical conduct and self-regulation. However, professionalism is also a personal thing, and nothing tests a doctor’s professionalism more than the tension between self-interest and the patient’s best interests — i...

Rifampicin for Staphylococcus aureus bacteraemia: give it ARREST